[Coral-List] Rotenon is probably anti-ichthyological?

Gomelyuk, Victor victor.gomelyuk at PLMBAY.PWCNT.NT.GOV.AU
Wed Sep 24 18:53:07 EDT 2003

"anti-microbial, anti-fungal,
anti-botanical compounds"

It is great!


Victor Gomelyuk

	-----Original Message-----
	From: ron price [mailto:rrp at ccs.nrl.navy.mil] 
	Sent: Monday, September 22, 2003 12:09 PM
	To: 'coral-list at coral.aoml.noaa.gov'
	Subject: RE: Coral-List Digest, Vol 3, Issue 17

	From: "craigdowns" craigdowns at envirtue.com

	If you can elucidate the biochemical pathway or obtain the gene(s)
	the proprotein that creates these anti-microbial, anti-fungal,
	anti-botanical compounds from coral, its possible that you could
	encapsulate these polypetides into a nano-structure (capsule) to be
	added to the paint instead of using something like TBT.  You would
	using the coral's own anti-foulant chemistry on your boat - and
	corals make it, there is a lower probability of toxic side affects
	the corals themselves (but that would have to be determined

	You might want to look at the work of Dan Gerhard, Dan Ritchoff, Sr.
	Avalon Mary, Ronald Price, Tony Clair et al who have done extensive
	with natural extracts and analogs from corals with great success
	the mid 80's.....Entrapment and release is a major part of this
	work....with the first successful coatings produced around 91 albet
	extracts from octocorals.  

	So far the methods have been to extract the compounds and try
	traditional synthesis in the lab to scale up production, you just
	imagine how wonderful it would be to have a range of these compounds
	that could be produced in quantity utilizing fermentation technology
	just how important it would be to the coatings industry in
	the next generation of coatings.....I'd love to work with anyone who
	thinking along these lines to develop a coating based on your novel

	Those of us who do this work can use collaborators with new and
	compounds to expand our library of effective agents,,,,

	Keep in mind that the corals produce many of these as secondary
	metabolites with a seemingly endless supply, those of us who
	the encapsulation systems and antifouling coatings must load all of
	repellent/toxicant at one go and it has to last for a minimum of 5-7
	years to be useful. Activities in the pico-gram or nano-gram per mil
	range would be best.....1 ug/ml/day at worst.

	Glad to see more interest as we need some fresh thinking and a new
	approach to solving production problems for these compounds. 


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