[Coral-List] postdoc computational biology of sponges
jaapk at science.uva.nl
Thu Oct 5 09:32:38 EDT 2006
Postdoc for the project ``Morphogenesis and gene regulatory networks in
plants and animals: a complex systems modelling approach (MORPHEX)''
The Section Computational Science of the University of Amsterdam has a
vacancy for a postdoc for the project ``Morphogenesis and gene regulatory
networks in plants and animals: a complex systems modelling approach
(MORPHEX)''. The project is an EU-funded project and is Collaboration with
the Centre National de la Recherche Scientifique - Delegation Rhone Auvergne
(CNRS) and other laboratories from France, Germany, Sweden and Norway. It is
a multi-disciplinary research project in which groups from computer science,
mathematics and developmental biology closely collaborate.
The main objective of the project is to obtain via a modelling and simulation
approach a better understanding of the structure and dynamics of metabolic
pathways and gene regulatory networks involved in the morphogenesis of animals
and plants. We will concentrate on the development of two kind of sponges and
on the organogenesis of carpel and anthers of a flowering plant. We will
tackle the complexity involved in these processes by using concepts and tools
arising from complex systems science. The following problems will be addressed:
provide a general model allowing to describe the underlying complex systems
at different hiearchical levels in the same formalism; provide tools to
extract concrete models description from experimental data; provide a way to
conduct in-silico experiments.
The postdoc will focus on modelling early development in sponge before
settlement/development and growth in the adult sponge, in close collaboration
with molecular biologists. The major scientific questions here are: i) to find
causal relations between genes in regulatory networks and to understand the
dynamics of these networks, through modelling and optimization techniques.
ii) To quantitatively reproduce and understand spatial and temporal expression
patterns in developmental processes in simulations and to compare these with
actually observed patterns. iii) To understand the physical coupling between
an aggregate of cells and the bodyplan formation in regulatory systems.
A PhD in scientific computing or computational science, (computational)
physics, chemistry, biology or a comparable expertise. Candidates are also
expected to have an active interest in life science applications. A strong
research record, evidenced by a PhD thesis and papers published in
peer-reviewed journals Ability to operate in an international research team.
Fluency in oral and written English.
Further information can be obtained from : Dr Jaap A. Kaandorp, Section
Computational Science, University of Amsterdam; e-mail: jaapk at science.uva.nl.
More information (application procedure, deadlines etc.) will soon become
available on the website http://www.uva.nl/vacatures
Dr. Jaap A. Kaandorp
Section Computational Science
Faculty of Science
University of Amsterdam
1098 SJ Amsterdam
Phone: +31 20 5257539 / +31 20 5257462
email: jaapk at science.uva.nl
fax: +31 20 5257490
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