[Coral-List] Rotenon is probably anti-ichthyological?
Gomelyuk, Victor
victor.gomelyuk at PLMBAY.PWCNT.NT.GOV.AU
Wed Sep 24 18:53:07 EDT 2003
"anti-microbial, anti-fungal,
anti-botanical compounds"
It is great!
Thanks.
Victor Gomelyuk
-----Original Message-----
From: ron price [mailto:rrp at ccs.nrl.navy.mil]
Sent: Monday, September 22, 2003 12:09 PM
To: 'coral-list at coral.aoml.noaa.gov'
Subject: RE: Coral-List Digest, Vol 3, Issue 17
From: "craigdowns" craigdowns at envirtue.com
If you can elucidate the biochemical pathway or obtain the gene(s)
to
the proprotein that creates these anti-microbial, anti-fungal,
anti-botanical compounds from coral, its possible that you could
encapsulate these polypetides into a nano-structure (capsule) to be
added to the paint instead of using something like TBT. You would
be
using the coral's own anti-foulant chemistry on your boat - and
since
corals make it, there is a lower probability of toxic side affects
on
the corals themselves (but that would have to be determined
experimentally).
You might want to look at the work of Dan Gerhard, Dan Ritchoff, Sr.
Avalon Mary, Ronald Price, Tony Clair et al who have done extensive
work
with natural extracts and analogs from corals with great success
since
the mid 80's.....Entrapment and release is a major part of this
work....with the first successful coatings produced around 91 albet
from
extracts from octocorals.
So far the methods have been to extract the compounds and try
traditional synthesis in the lab to scale up production, you just
cannot
imagine how wonderful it would be to have a range of these compounds
that could be produced in quantity utilizing fermentation technology
and
just how important it would be to the coatings industry in
formulating
the next generation of coatings.....I'd love to work with anyone who
is
thinking along these lines to develop a coating based on your novel
compounds.
Those of us who do this work can use collaborators with new and
novel
compounds to expand our library of effective agents,,,,
Keep in mind that the corals produce many of these as secondary
metabolites with a seemingly endless supply, those of us who
formulate
the encapsulation systems and antifouling coatings must load all of
the
repellent/toxicant at one go and it has to last for a minimum of 5-7
years to be useful. Activities in the pico-gram or nano-gram per mil
range would be best.....1 ug/ml/day at worst.
Glad to see more interest as we need some fresh thinking and a new
approach to solving production problems for these compounds.
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